Genetic susceptibility to lead poisoning.
نویسندگان
چکیده
منابع مشابه
Genetic susceptibility to lead poisoning.
Major strides have been taken in the regulation of lead intoxication in the general population, but studies using genetic markers of susceptibility to environmental toxicants raise the question of whether genes can make certain individuals more vulnerable to environmental toxins such as lead. At least three polymorphic genes have been identified that potentially can influence the bioaccumulatio...
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Introduction: Lead is a toxic metal that is found in the earth's crust and has been used by humans since 7000 years ago due to its density, malleability, high resistance and low melting point. The wide use of this metal in the industry, in addition to the exposure of workers, has led to widespread environmental pollution and public health problems in many parts of the world. Due to the widespre...
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Previous reports have shown that blood lead levels in humans are associated with a polymorphic form of delta-aminolevulinate dehydratase (ALAD), an enzyme of heme biosynthesis that binds and is inhibited by lead. We hypothesized that ALAD levels may influence the distribution and accumulation of lead in the blood and target organs. To assess this, we studied strains of mice that differ in the n...
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Adverse effects of lead on human health have been recognized for centuries. Nevertheless , current public health measures require a greater understanding of the pathobiology of chronic low level exposure (1-3). Such considerations are related to the question of what level of lead intake is harmful and why specific clinical manifestations of lead poisoning are encountered under particular circum...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2000
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.00108s123